A historical catalogue of felt earthquakes in the Maltese islands has been compiled dating back to 1530. Although no fatalities were officially recorded during this time as a direct consequence of earthquake effects, serious damage to buildings occurred several times. In the catalogue time period, the islands experienced EMS-98 intensity VII-VIII once (11 January 1693) and intensity VII, or VI-VII five times. The northern segment of the Hyblean-Malta plateau is the source region which appears to pose the greatest threat, although large Greek events and lower magnitude Sicily Channel events also produced damage. Estimates of return periods for intensity ≥V are presented, and it is shown that expected peak ground accelerations justify the implementation of, at least, minimum anti-seismic provisions. The rapid and continual increase in the local building stock on the densely-populated islands warrants the implementation of an appropriate seismic building code to be enforced.